Article
Genetic associations of single nucleotide polymorphisms in the l-DOPA receptor (GPR143) gene with severity of nicotine dependence in Japanese individuals, and attenuation of nicotine reinforcement in Gpr143 gene-deficient mice.
Journal of pharmacological sciences - 1 Oct 2020
Masukawa Daiki, Nishizawa Daisuke, Kanai Kaori, Kitamura Satoshi, Kasahara Yuka, Hashimoto Tatsuo, Takahagi Ryo, Hasegawa Junko, Nakayama Kyoko, Sato Naomi, Tanioka Fumihiko, Sugimura Haruhiko, Ikeda Kazutaka, Goshima Yoshio
Abstract excerpt
l-3,4-dihydroxyphenylalanine (l-DOPA) is a candidate neurotransmitter. l-DOPA is released by nicotine through nicotinic receptors. Recently, G-protein coupled receptor GPR143, was identified as a receptor for l-DOPA. In this study, genetic association studies between GPR143 genetic polymorphisms and smoking behaviors revealed that the single-nucleotide polymorphism rs6640499, in the GPR143 gene, was associated...
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