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Article

A candidate gene of Alzheimer diseases was mutated in senescence-accelerated mouse prone (SAMP) 8 mice.

Biochemical and biophysical research communications - 1 Oct 2021

Akbor Maruf Mohammad, Kim Juhyon, Nomura Mai, Sugioka Juno, Kurosawa Nobuyuki, Isobe Masaharu

Abstract excerpt

The senescence-accelerated mouse prone (SAMP) 8 strain exhibits age-related learning and memory deficits (LMD) at 2 months of age. We have found strong association of chromosome 12 locus with learning memory deficit (LMD) phenotype in SAMP8 strain. In the course of searching candidate gene, here we identified solute carrier family 24 sodium/potassium/calcium exchanger member 4 (Slc24a4) in SAMP8 chromosome 12 LMD...

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Identifiers

PMID: 34364289
DOI: 10.1016/j.bbrc.2021.07.095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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