Article
Mouse Models with SGLT2 Mutations: Toward Understanding the Role of SGLT2 beyond Glucose Reabsorption.
International journal of molecular sciences - 27 Mar 2023
Unno Keiko, Taguchi Kyoko, Takagi Yoshiichi, Hase Tadashi, Meguro Shinichi, Nakamura Yoriyuki
Abstract excerpt
The sodium-glucose cotransporter 2 (SGLT2) mainly carries out glucose reabsorption in the kidney. Familial renal glycosuria, which is a mutation of SGLT2, is known to excrete glucose in the urine, but blood glucose levels are almost normal. Therefore, SGLT2 inhibitors are attracting attention as a new therapeutic drug for diabetes, which is increasing worldwide. In fact, SGLT2 inhibitors not only suppress...
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