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The transcription factor PITX1 drives astrocyte differentiation by regulating the SOX9 gene

6 Aug 2020

Abstract excerpt

Astrocytes perform multiple essential functions in the developing and mature brain, including regulation of synapse formation, control of neurotransmitter release and uptake, and maintenance of extracellular ion balance. As a result, astrocytes have been implicated in the progression of neurodegenerative disorders such as Alzheimer's disease, Huntington's disease, and Parkinson's disease. Despite these critical...

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PMID: 32759168
DOI: 10.1074/jbc.ra120.013352

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