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Article

Etiology, Risk Factors, and Biomarkers in Systemic Sclerosis with Interstitial Lung Disease.

American journal of respiratory and critical care medicine - 15 Mar 2020

Khanna Dinesh, Tashkin Donald P, Denton Christopher P, Renzoni Elisabetta A, Desai Sujal R, Varga John

Abstract excerpt

Systemic sclerosis (SSc) is a complex, multiorgan, autoimmune disease. Lung fibrosis occurs in ∼80% of patients with SSc; 25% to 30% develop progressive interstitial lung disease (ILD). The pathogenesis of fibrosis in SSc-associated ILD (SSc-ILD) involves cellular injury, activation/differentiation of mesenchymal cells, and morphological/biological changes in epithelial/endothelial cells. Risk factors for...

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Identifiers

PMID: 31841044
DOI: 10.1164/rccm.201903-0563CI
PMCID: PMC7068837

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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