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Article

MDM2-Mediated Ubiquitination of Angiotensin-Converting Enzyme 2 Contributes to the Development of Pulmonary Arterial Hypertension.

Circulation - 22 Sept 2020

Shen Hui, Zhang Jiao, Wang Chen, Jain Pritesh P, Xiong Mingmei, Shi Xinxing, Lei Yuyang, Chen Shanshan, Yin Qian, Thistlethwaite Patricia A, Wang Jian, Gong Kaizheng, Yuan Zu-Yi, Yuan Jason X-J, Shyy John Y-J

Abstract excerpt

BACKGROUND: Angiotensin-converting enzyme 2 (ACE2) converts angiotensin II, a potent vasoconstrictor, to angiotensin-(1-7) and is also a membrane protein that enables coronavirus disease 2019 (COVID-19) infectivity. AMP-activated protein kinase (AMPK) phosphorylation of ACE2 enhances ACE2 stability. This mode of posttranslational modification of ACE2 in vascular endothelial cells is causative of a pulmonary...

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Identifiers

PMID: 32755395
DOI: 10.1161/CIRCULATIONAHA.120.048191
PMCID: PMC7497891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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