Article
Distinct splicing signatures affect converged pathways in myelodysplastic syndrome patients carrying mutations in different splicing regulators.
RNA (New York, N.Y.) - 1 Oct 2016
Qiu Jinsong, Zhou Bing, Thol Felicitas, Zhou Yu, Chen Liang, Shao Changwei, DeBoever Christopher, Hou Jiayi, Li Hairi, Chaturvedi Anuhar, Ganser Arnold, Bejar Rafael, Zhang Dong-Er, Fu Xiang-Dong, Heuser Michael
Abstract excerpt
Myelodysplastic syndromes (MDS) are heterogeneous myeloid disorders with prevalent mutations in several splicing factors, but the splicing programs linked to specific mutations or MDS in general remain to be systematically defined. We applied RASL-seq, a sensitive and cost-effective platform, to interrogate 5502 annotated splicing events in 169 samples from MDS patients or healthy individuals. We found that...
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