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Manganese homeostasis and utilization in pathogenic bacteria

21 Apr 2015

Abstract excerpt

Manganese (Mn) is a required cofactor for all forms of life. Given the importance of Mn to bacteria, the host has devised strategies to sequester Mn from invaders. In the macrophage phagosome, NRAMP1 removes Mn and other essential metals to starve intracellular pathogens; in the extracellular space, calprotectin chelates Mn and Zn. Calprotectin-mediated Mn sequestration is a newly appreciated host defense...

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PMID: 25898914
DOI: 10.1111/mmi.13034

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