Article
On the complexity measures of mutation hotspots in human TP53 protein.
Chaos (Woodbury, N.Y.) - 1 Jul 2020
Ding Yan, Xue Hongsheng, Ding Xinjia, Zhao Yuqing, Zhao Zhilong, Wang Dazhi, Wu Jianlin
Abstract excerpt
The role of sequence complexity in 23 051 somatic missense mutations including 73 well-known mutation hotspots across 22 major cancers was studied in human TP53 proteins. A role for sequence complexity in TP53 protein mutations is suggested since (i) the mutation rate significantly increases in low amino acid pair bias complexity; (ii) probability distribution complexity increases following single point...
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