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Article

Epistatic interactions involving DRD2, DRD4, and COMT polymorphisms and risk of substance abuse in women with binge-purge eating disturbances.

Journal of psychiatric research - 1 Jun 2016

Steiger Howard, Thaler Lea, Gauvin Lise, Joober Ridha, Labbe Aurelie, Israel Mimi, Kucer Audrey

Abstract excerpt

Substance abuse is common in individuals with bulimia-spectrum (binge-purge) eating disturbances, a co-occurrence that has been attributed to shared neurobiological substrates--notably alterations in dopaminergic activity. We examined the implications of variations of selected, dopamine-relevant polymorphisms (DRD2 Taq1A, DRD4 7R, and COMT) for risk of substance abuse in women with binge-purge eating syndromes....

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Source

Identifiers

PMID: 26950642
DOI: 10.1016/j.jpsychires.2016.02.011

Genes

COMT
DRD4
DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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