Article
Long forms of the dopamine receptor (DRD4) gene VNTR are more prevalent in substance abusers: no interaction with functional alleles of the catechol-o-methyltransferase (COMT) gene.
American journal of medical genetics - 9 Oct 2000
Vandenbergh D J, Rodriguez L A, Hivert E, Schiller J H, Villareal G, Pugh E W, Lachman H, Uhl G R
Abstract excerpt
Substance abuse is a complex behavior that is caused by both environmental and genetic factors. Work to understand the genetic factors has focused on genes related to dopamine activity because of its critical role in rewarding and reinforcing behaviors. The DRD3 and other dopamine receptor subtypes are expressed in many areas of the limbic system, and have been the objects of study for their possible roles in...
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