Article
Dopamine D4 receptor VNTR polymorphism associated with greater risk for substance abuse among adolescents with disruptive behavior disorders: Preliminary results.
The American journal on addictions - 1 Jan 2016
Mallard Travis T, Doorley James, Esposito-Smythers Christianne L, McGeary John E
Abstract excerpt
BACKGROUND AND OBJECTIVES: The variable number tandem repeats (VNTR) polymorphism of the dopamine D4 receptor gene (DRD4) has received considerable attention as a potential genetic contributor to addiction. However, is unclear whether the polymorphism is involved in developing general traits that lead to risky behavior or an intermediate phenotype more specific to substance use disorders. Association studies have...
Topics
- Adolescent
- Attention Deficit and Disruptive Behavior Disorders
- Female
- Genetic Predisposition to Disease
- Heterozygote
- Humans
- Male
- Minisatellite Repeats
- Polymorphism, Genetic
- Receptors, Dopamine D4
- Substance-Related Disorders