Article
Tuning the circadian period of cyanobacteria up to 6.6 days by the single amino acid substitutions in KaiC.
Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2020
Ito-Miwa Kumiko, Furuike Yoshihiko, Akiyama Shuji, Kondo Takao
Abstract excerpt
The circadian clock of cyanobacteria consists of only three clock proteins, KaiA, KaiB, and KaiC, which generate a circadian rhythm of KaiC phosphorylation in vitro. The adenosine triphosphatase (ATPase) activity of KaiC is the source of the 24-h period and temperature compensation. Although numerous circadian mutants of KaiC have been identified, the tuning mechanism of the 24-h period remains unclear. Here, we...
Topics
- Adenosine Triphosphatases
- Amino Acid Substitution
- Bacterial Proteins
- Circadian Clocks
- Circadian Rhythm
- Circadian Rhythm Signaling Peptides and Proteins
- Cyanobacteria
- Gene Expression Regulation, Bacterial
- Mutation