Article
The roles of the dimeric and tetrameric structures of the clock protein KaiB in the generation of circadian oscillations in cyanobacteria.
The Journal of biological chemistry - 24 Aug 2012
Murakami Reiko, Mutoh Risa, Iwase Ryo, Furukawa Yukio, Imada Katsumi, Onai Kiyoshi, Morishita Megumi, Yasui So, Ishii Kentaro, Valencia Swain Jonathan Orville, Uzumaki Tatsuya, Namba Keiichi, Ishiura Masahiro
Abstract excerpt
The molecular machinery of the cyanobacterial circadian clock consists of three proteins, KaiA, KaiB, and KaiC. The three Kai proteins interact with each other and generate circadian oscillations in vitro in the presence of ATP (an in vitro KaiABC clock system). KaiB consists of four subunits organized as a dimer of dimers, and its overall shape is that of an elongated hexagonal plate with a positively charged...
Topics
- Activity Cycles
- Bacterial Proteins
- Circadian Clocks
- Circadian Rhythm Signaling Peptides and Proteins
- Cyanobacteria
- Gene Expression Regulation, Bacterial
- Mutation
- Protein Multimerization
- Protein Structure, Quaternary