Article
KaiA-stimulated KaiC phosphorylation in circadian timing loops in cyanobacteria.
Proceedings of the National Academy of Sciences of the United States of America - 26 Nov 2002
Iwasaki Hideo, Nishiwaki Taeko, Kitayama Yohko, Nakajima Masato, Kondo Takao
Abstract excerpt
Cyanobacterial clock proteins KaiA and KaiC are proposed as positive and negative regulators in the autoregulatory circadian kaiBC expression, respectively. Here, we show that activation of kaiBC expression by kaiA requires KaiC, suggesting a positive feedback control in the cyanobacterial clockwork. We found that robust circadian phosphorylation of KaiC. KaiA was essential for in vivo KaiC phosphorylation and...
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