Article
Intramolecular regulation of phosphorylation status of the circadian clock protein KaiC.
PloS one - 25 Nov 2009
Xu Yao, Mori Tetsuya, Qin Ximing, Yan Heping, Egli Martin, Johnson Carl Hirschie
Abstract excerpt
BACKGROUND: KaiC, a central clock protein in cyanobacteria, undergoes circadian oscillations between hypophosphorylated and hyperphosphorylated forms in vivo and in vitro. Structural analyses of KaiC crystals have identified threonine and serine residues in KaiC at three residues (T426, S431, and T432) as potential sites at which KaiC is phosphorylated; mutation of any of these three sites to alanine abolishes...
Topics
- Bacterial Proteins
- Binding Sites
- Circadian Rhythm
- Circadian Rhythm Signaling Peptides and Proteins
- Crystallography, X-Ray
- Cyanobacteria
- Gene Expression Regulation, Bacterial
- Kinetics
- Models, Biological
- Mutation