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Article

Endothelial nitric oxide synthase gene: prospects for treatment of heart disease.

Pharmacogenomics - 1 Dec 2007

Cooke Glen E, Doshi Amit, Binkley Philip F

Abstract excerpt

Nitric oxide functions as a signaling molecule with a well-established role in vascular homeostasis. It is synthesized from the oxidation of L-arginine by the enzyme, endothelial nitric oxide synthase (eNOS). The eNOS gene has a number of polymorphic sites, including SNPs, dinucleotide repeats and variable number tandem repeat sequences, and the opportunity exists to investigate polymorphic functional correlates...

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PMID: 18086002
DOI: 10.2217/14622416.8.12.1723

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