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Article

Relevance of Higher-Order Epistasis in Drug Resistance.

Molecular biology and evolution - 4 Jan 2021

Lozovsky Elena R, Daniels Rachel F, Heffernan Gavin D, Jacobus David P, Hartl Daniel L

Abstract excerpt

We studied five chemically distinct but related 1,3,5-triazine antifolates with regard to their effects on growth of a set of mutants in dihydrofolate reductase. The mutants comprise a combinatorially complete data set of all 16 possible combinations of four amino acid replacements associated with resistance to pyrimethamine in the malaria parasite Plasmodium falciparum. Pyrimethamine was a mainstay medication...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32745183
DOI: 10.1093/molbev/msaa196
PMCID: PMC7782864

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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