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Article

Synergistic activation of AMPK prevents from polyglutamine-induced toxicity in Caenorhabditis elegans.

Pharmacological research - 1 Nov 2020

Gómez-Escribano A P, Bono-Yagüe J, García-Gimeno M A, Sequedo M D, Hervás D, Fornés-Ferrer V, Torres-Sánchez S C, Millán J M, Sanz P, Vázquez-Manrique R P

Abstract excerpt

Expression of abnormally long polyglutamine (polyQ) tracks is the source of a range of dominant neurodegenerative diseases, such as Huntington disease. Currently, there is no treatment for this devastating disease, although some chemicals, e.g., metformin, have been proposed as therapeutic solutions. In this work, we show that metformin, together with salicylate, can synergistically reduce the number of...

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Identifiers

PMID: 32739430
DOI: 10.1016/j.phrs.2020.105105
PMCID: PMC7755709

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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