Article
The Caenorhabditis elegans AMP-activated protein kinase AAK-2 is phosphorylated by LKB1 and is required for resistance to oxidative stress and for normal motility and foraging behavior.
The Journal of biological chemistry - 30 May 2008
Lee Hyojin, Cho Jeong Soo, Lambacher Nils, Lee Jieun, Lee Se-Jin, Lee Tae Hoon, Gartner Anton, Koo Hyeon-Sook
Abstract excerpt
AAK-2 is one of two alpha isoforms of the AMP-activated protein kinase in Caenorhabditis elegans and is involved in life span maintenance, stress responses, and germ cell cycle arrest upon dauer entry. We found that AAK-2 was phosphorylated at threonine 243 in response to paraquat treatment and that this phosphorylation depends on PAR-4, the C. elegans LKB1 homologue. Both aak-2 mutation and par-4 knockdown...
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