Sex-dependent differences in pain and sleep in a porcine model of Neurofibromatosis type 1

Abstract excerpt

Neurofibromatosis Type 1 (NF1) is an autosomal dominant genetic disorder resulting from germline mutations in the NF1 gene, which encodes neurofibromin. Patients experience a variety of symptoms, but pain in the context of NF1 remains largely underrecognized. Here, we characterize nociceptive signaling and pain behaviors in a miniswine harboring a disruptive NF1 mutation (exon 42 deletion). We explore these phen...

Topics

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• Cafe-au-Lait Spots
• Ganglia, Spinal
• GTPase-Activating Proteins
• Learning
• Memory
• Neurofibroma
• Neurofibromatosis 1
• Neurofibromin 1

Identifiers and source

Literature Corpus work

7cb1aeab-d600-5cd3-96b0-0bf735a3e44a

DOI

10.1101/495358