Article
The Periostin/Integrin-αv Axis Regulates the Size of Hematopoietic Stem Cell Pool in the Fetal Liver.
Stem cell reports - 11 Aug 2020
Biswas Atreyi, Roy Irene M, Babu Prathibha C, Manesia Javed, Schouteden Sarah, Vijayakurup Vinod, Anto Ruby John, Huelsken Joerg, Lacy-Hulbert Adam, Verfaillie Catherine M, Khurana Satish
Abstract excerpt
We earlier showed that outside-in integrin signaling through POSTN-ITGAV interaction plays an important role in regulating adult hematopoietic stem cell (HSC) quiescence. Here, we show that Itgav deletion results in increased frequency of phenotypic HSCs in fetal liver (FL) due to faster proliferation. Systemic deletion of Postn led to increased proliferation of FL HSCs, albeit without any loss of stemness,...
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