Article
Endothelial Cell-Selective Adhesion Molecule Contributes to the Development of Definitive Hematopoiesis in the Fetal Liver.
Stem cell reports - 10 Dec 2019
Ueda Tomoaki, Yokota Takafumi, Okuzaki Daisuke, Uno Yoshihiro, Mashimo Tomoji, Kubota Yoshiaki, Sudo Takao, Ishibashi Tomohiko, Shingai Yasuhiro, Doi Yukiko, Ozawa Takayuki, Nakai Ritsuko, Tanimura Akira, Ichii Michiko, Ezoe Sachiko, Shibayama Hirohiko, Oritani Kenji, Kanakura Yuzuru
Abstract excerpt
Endothelial cell-selective adhesion molecule (ESAM) is a lifelong marker of hematopoietic stem cells (HSCs). Although we previously elucidated the functional importance of ESAM in HSCs in stress-induced hematopoiesis in adults, it is unclear how ESAM affects hematopoietic development during fetal life. To address this issue, we analyzed fetuses from conventional or conditional ESAM-knockout mice. Approximately...
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