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Enhanced hematovascular contribution of SCL 3' enhancer expressing fetal liver cells uncovers their potential to integrate in extramedullary adult niches.

Stem cells (Dayton, Ohio) - 1 Jan 2010

Garcia-Ortega Antonio M, Cañete Ana, Quinter Cristina, Silberstein Lev, Piquer-Gil Marina, Alvarez-Dolado Manuel, Dekel Benjamin, Gottgens Berthild, Sánchez María-José

Abstract excerpt

Fetal liver (FL) hematopoietic progenitors have superior blood engraftment competence compared with adult bone marrow (BM), however less is known about FL in vivo vascular capacity. Here we show in transplantation assays that FL cells possess enhanced vascular endothelial potential compared with adult bone marrow. We generated high-level hematopoietic chimeras using donor cells from mice transgenic for the stem...

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PMID: 19785037
DOI: 10.1002/stem.228

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