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Autophagy regulates the maturation of hematopoietic precursors in the embryo

15 Mar 2024

Abstract excerpt

An understanding of the mechanisms regulating embryonic hematopoietic stem cell (HSC) development would facilitate their regeneration. The aorta-gonad-mesonephros region is the site for HSC production from hemogenic endothelial cells (HEC). While several distinct regulators are involved in this process, it is not yet known whether macroautophagy (autophagy) plays a role in hematopoiesis in the pre-liver stage....

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PMID: 38490977
DOI: 10.1038/s41467-024-46453-y

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