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Fetal hepatocytes protect the HSPC genome via fetuin-A

4 Dec 2024

Abstract excerpt

The maintenance of genomic integrity in rapidly proliferating cells is a substantial challenge during embryonic development1–3. Although numerous cell-intrinsic mechanisms have been revealed4–7, little is known about genome-protective effects and influences of developmental tissue microenvironments on tissue-forming cells. Here we show that fetal liver hepatocytes provide protection to haematopoietic stem and...

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PMID: 39633051
DOI: 10.1038/s41586-024-08307-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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