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Article

Genes regulated by BCL11B during T-cell development are enriched for de novo mutations found in schizophrenia patients.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Sept 2020

Fahey Laura, Donohoe Gary, Broin Pilib Ó, Morris Derek W

Abstract excerpt

While abnormal neurodevelopment contributes to schizophrenia (SCZ) risk, there is also evidence to support a role for immune dysfunction in SCZ. BCL11B, associated with SCZ in genome-wide association study (GWAS), is a transcription factor that regulates the differentiation and development of cells in the central nervous and immune systems. Here, we use functional genomics data from studies of BCL11B to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32729240
DOI: 10.1002/ajmg.b.32811

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