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Article

Unraveling the Mysteries of PAX8 in Reproductive Tract Cancers

23 Dec 2020

Abstract excerpt

Paired Box 8 (PAX8) is a lineage-specific transcription factor that has essential roles during embryogenesis and tumorigenesis. The importance of PAX8 in the development of the reproductive system is highlighted by abnormalities observed upon the loss or mutation of this PAX family member. In cancer, PAX8 expression is deregulated in a key set of neoplasms, including those arising from the Müllerian ducts. The...

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PMID: 33361393
DOI: 10.1158/0008-5472.can-20-3173

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