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Gut microbes and their metabolites in relation to the classic tumor suppressor gene P53: a novel narrative

17 Jul 2025

Abstract excerpt

Gut microbes are considered to be key factors regulating host health and are closely related to tumorigenesis. Although the exact mechanism has not been clearly explained, many studies have shown that specific bacteria can affect cancer-related bioactive molecules, such as p53, Wnt, MAPK, and EGFR. Among them, p53 is the most commonly mutated gene in all tumor types. In this review, we systematically examine the...

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PMID: 40675970
DOI: 10.1038/s41522-025-00775-x

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