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The Role of Human LRRK2 in Methylmercury-Induced Inhibition of Microvesicle Formation of Cephalic Neurons in Caenorhabditis elegans.

Neurotoxicity research - 1 Oct 2020

Ke Tao, Santamaria Abel, Rocha Joao B T, Tinkov Alexey A, Lu Rongzhu, Bowman Aaron B, Aschner Michael

Abstract excerpt

In a previous study, we have shown that methylmercury (MeHg) exposure causes focal aggregation of intracellular transgenic mCherry protein in dendrites of cephalic (CEP) neurons in Caenorhabditis elegans (C. elegans). However, the underlying mechanism is unknown. We hypothesized that reduced cellular release of mCherry via extracellular vesicles by MeHg contributes to its accumulation and intracellular...

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Identifiers

PMID: 32725544
DOI: 10.1007/s12640-020-00262-5
PMCID: PMC7484354

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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