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Mutations at Two Key Sites in PP2A Safeguard Caenorhabditis elegans Neurons from Microcystin-LR Toxicity.

Toxins - 13 Mar 2024

Zhan Chunhua, Gong Jianke

Abstract excerpt

Microcystin-LR (MC-LR) is a secondary metabolite produced by cyanobacteria, globally renowned for its potent hepatotoxicity. However, an increasing body of research suggests that it also exhibits pronounced neurotoxicity. PP2A is a fundamental intracellular phosphatase that plays a pivotal role in cell development and survival. Although extensive research has focused on the binding of MC-LR to the C subunit of...

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PMID: 38535811
DOI: 10.3390/toxins16030145
PMCID: PMC10974068

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