Article
Intracellular trafficking pathways in silver nanoparticle uptake and toxicity in Caenorhabditis elegans.
Nanotoxicology - 1 Sept 2016
Maurer Laura L, Yang Xinyu, Schindler Adam J, Taggart Ross K, Jiang Chuanjia, Hsu-Kim Heileen, Sherwood David R, Meyer Joel N
Abstract excerpt
We used the nematode Caenorhabditis elegans to study the roles of endocytosis and lysosomal function in uptake and subsequent toxicity of silver nanoparticles (AgNP) in vivo. To focus on AgNP uptake and effects rather than silver ion (AgNO3) effects, we used a minimally dissolvable AgNP, citrate-coated AgNPs (CIT-AgNPs). We found that the clathrin-mediated endocytosis inhibitor chlorpromazine reduced the toxicity...
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