Human meningiomas arise from developmental meningeal mosaicism

Abstract excerpt

Meningioma is the most common primary intracranial tumour, yet its genetic origin and the temporal sequence of mutational events remain poorly defined. Here, we analysed 80 triple-matched tumour, histologically normal meninges, and blood samples from 22 patients. NF2 or TRAF7 driver mutations are detectable in phenotypically normal meninges in 81.8% of cases (95% CI: 59.7–94.8%; VAF ∼0.02%), corroborated by high...

Topics

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• Chromosomes, Human, Pair 22
• Clonal Evolution
• CREB-Binding Protein
• Exome Sequencing
• INDEL Mutation
• Meningeal Neoplasms
• Meningioma
• Neurofibromin 2

Identifiers and source

Literature Corpus work

ba2bef2f-5620-59c9-b7ad-ac84574f4093

DOI

10.64898/2026.06.13.732068