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Article

Implementation of a human podocyte injury model of chronic kidney disease for profiling of renoprotective compounds.

European journal of pharmacology - 15 Nov 2017

Abraham Vivek C, Miller Loan N, Pratt Steve D, Putman Brent, Kim Laura, Gopalakrishnan Sujatha M, King Andrew

Abstract excerpt

Degradation of podocyte structural integrity and function are hallmarks of proteinuric chronic kidney disease. In vivo, injury of podocytes manifests itself in the form of disruption of foot process morphology and associated cytoskeletal architecture, de-differentiation, and loss of adhesion to the glomerular basement membrane. Given the critical role played by this highly specialized cell type in maintaining...

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PMID: 28899697
DOI: 10.1016/j.ejphar.2017.09.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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