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Article

EP4 signalling is essential for controlling islet inflammation by causing a shift in macrophage polarization in obesity/type 2 diabetes.

Diabetes & vascular disease research - 1 Jan 2000

Yasui-Kato Mika, Patlada Suthomwong, Yokode Masayuki, Kamei Kaeko, Minami Manabu

Abstract excerpt

Activation of the prostaglandin E2 receptor EP4 alters polarization of adipose tissue macrophages towards the anti-inflammatory M2 phenotype to suppress chronic inflammation. However, the role of EP4 signalling in pancreatic macrophages that affect insulin secretion is unclear. We examined the role of EP4 signalling in islet inflammation in vitro and in vivo. Obese diabetic db/db mice were treated with an...

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Identifiers

PMID: 32722929
DOI: 10.1177/1479164120945675
PMCID: PMC7510360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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