Article
Genetic copy number variants, cognition and psychosis: a meta-analysis and a family study.
Molecular psychiatry - 1 Sept 2021
Thygesen Johan H, Presman Amelia, Harju-Seppänen Jasmine, Irizar Haritz, Jones Rebecca, Kuchenbaecker Karoline, Lin Kuang, Alizadeh Behrooz Z, Austin-Zimmerman Isabelle, Bartels-Velthuis Agna, Bhat Anjali, Bruggeman Richard, Cahn Wiepke, Calafato Stella, Crespo-Facorro Benedicto, de Haan Liewe, de Zwarte Sonja M C, Di Forti Marta, Díez-Revuelta Álvaro, Hall Jeremy, Hall Mei-Hua, Iyegbe Conrad, Jablensky Assen, Kahn Rene, Kalaydjieva Luba, Kravariti Eugenia, Lawrie Stephen, Luykx Jurjen J, Mata Igancio, McDonald Colm, McIntosh Andrew M, McQuillin Andrew, Muir Rebecca, Ophoff Roel, Picchioni Marco, Prata Diana P, Ranlund Siri, Rujescu Dan, Rutten Bart P F, Schulze Katja, Shaikh Madiha, Schirmbeck Frederike, Simons Claudia J P, Toulopoulou Timothea, van Amelsvoort Therese, van Haren Neeltje, van Os Jim, van Winkel Ruud, Vassos Evangelos, Walshe Muriel, Weisbrod Matthias, Zartaloudi Eirini, Bell Vaughan, Powell John, Lewis Cathryn M, Murray Robin M, Bramon Elvira
Abstract excerpt
The burden of large and rare copy number genetic variants (CNVs) as well as certain specific CNVs increase the risk of developing schizophrenia. Several cognitive measures are purported schizophrenia endophenotypes and may represent an intermediate point between genetics and the illness. This paper investigates the influence of CNVs on cognition. We conducted a systematic review and meta-analysis of the...
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