Article
Genetic copy number variation and general cognitive ability.
PloS one - 1 Jan 2012
MacLeod Andrew K, Davies Gail, Payton Antony, Tenesa Albert, Harris Sarah E, Liewald David, Ke Xiayi, Luciano Michelle, Lopez Lorna M, Gow Alan J, Corley Janie, Redmond Paul, McNeill Geraldine, Pickles Andrew, Ollier William, Horan Michael, Starr John M, Pendleton Neil, Thomson Pippa A, Porteous David J, Deary Ian J
Abstract excerpt
Differences in genomic structure between individuals are ubiquitous features of human genetic variation. Specific copy number variants (CNVs) have been associated with susceptibility to numerous complex psychiatric disorders, including attention-deficit-hyperactivity disorder, autism-spectrum disorders and schizophrenia. These disorders often display co-morbidity with low intelligence. Rare chromosomal deletions...
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