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Article

Rare Copy Number Variants Are Associated With Poorer Cognition in Schizophrenia.

Biological psychiatry - 1 Jul 2021

Hubbard Leon, Rees Elliott, Morris Derek W, Lynham Amy J, Richards Alex L, Pardiñas Antonio F, Legge Sophie E, Harold Denise, Zammit Stanley, Corvin Aiden C, Gill Michael G, Hall Jeremy, Holmans Peter, O'Donovan Michael C, Owen Michael J, Donohoe Gary, Kirov George, Pocklington Andrew, Walters James T R

Abstract excerpt

BACKGROUND: Cognitive impairment in schizophrenia is a major contributor to poor outcomes, yet its causes are poorly understood. Some rare copy number variants (CNVs) are associated with schizophrenia risk and affect cognition in healthy populations, but their contribution to cognitive impairment in schizophrenia has not been investigated. We examined the effect of 12 schizophrenia CNVs on cognition in those with...

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Identifiers

PMID: 33678419
DOI: 10.1016/j.biopsych.2020.11.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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