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Article

Single-cell RNA sequencing identifies inflammatory tissue T cells in eosinophilic esophagitis

7 Apr 2019

Abstract excerpt

T cell heterogeneity is highly relevant to allergic disorders. We resolved the heterogeneity of human tissue CD3+ T cells during allergic inflammation, focusing on a tissue-specific allergic disease, eosinophilic esophagitis (EoE). We investigated 1088 single T cells derived from patients with a spectrum of disease activity. Eight disparate tissue T cell subtypes (designated T1-T8) were identified, with T7 and T8...

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PMID: 30958799
DOI: 10.1172/jci125917

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