Article
Cooperative participation of epigenomic and genomic alterations in the clinicopathological diversity of gastric adenocarcinomas: significance of cell adhesion and epithelial-mesenchymal transition-related signaling pathways.
Carcinogenesis - 13 Nov 2020
Yang Menghan, Arai Eri, Takahashi Yoriko, Totsuka Hirohiko, Chiku Suenori, Taniguchi Hirokazu, Katai Hitoshi, Sakamoto Hiromi, Yoshida Teruhiko, Kanai Yae
Abstract excerpt
The present study was conducted to clarify the cooperative significance of epigenomic and genomic abnormalities during gastric carcinogenesis. Using 21 samples of normal control gastric mucosa (C), 109 samples of non-cancerous gastric mucosa (N) and 105 samples of cancerous tissue (T) from 109 patients with primary gastric adenocarcinomas, genome-wide DNA methylation analysis was performed using Infinium assay....
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