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Article

Somatic alterations and mutational burden are potential predictive factors for metachronous development of early gastric cancer.

Scientific reports - 16 Dec 2020

Sakuta Kazuhiro, Sasaki Yu, Abe Yasuhiko, Sato Hidenori, Shoji Masakuni, Yaoita Takao, Yagi Makoto, Mizumoto Naoko, Onozato Yusuke, Kon Takashi, Koseki Ayumi, Sato Sonoko, Murakami Ryoko, Miyano Yuki, Ueno Yoshiyuki

Abstract excerpt

The risk of developing metachronous gastric cancer (MGC) following curative endoscopic submucosal dissection (ESD) of early gastric cancer (EGC) remains even after eradicating Helicobacter pylori (HP) successfully. We screened initial EGC and adjacent non-cancerous mucosa ESD-resected specimens for somatic variants of 409 cancer-related genes, assessing their mutational burden (MB) to predict molecular markers...

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Identifiers

PMID: 33328548
DOI: 10.1038/s41598-020-79195-0
PMCID: PMC7745026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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