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Article

Evaluating shared genetic influences on nonsyndromic cleft lip/palate and oropharyngeal neoplasms.

Genetic epidemiology - 1 Nov 2020

Howe Laurence J, Hemani Gibran, Lesseur Corina, Gaborieau Valérie, Ludwig Kerstin U, Mangold Elisabeth, Brennan Paul, Ness Andy R, St Pourcain Beate, Davey Smith George, Lewis Sarah J

Abstract excerpt

It has been hypothesised that nonsyndromic cleft lip/palate (nsCL/P) and cancer may share aetiological risk factors. Population studies have found inconsistent evidence for increased incidence of cancer in nsCL/P cases, but several genes (e.g., CDH1, AXIN2) have been implicated in the aetiologies of both phenotypes. We aimed to evaluate shared genetic aetiology between nsCL/P and oral cavity/oropharyngeal cancers...

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Identifiers

PMID: 32710482
DOI: 10.1002/gepi.22343
PMCID: PMC8240308

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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