Genome‐wide interaction studies identify sex‐specific risk alleles for nonsyndromic orofacial clefts

Abstract excerpt

Abstract Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is the most common craniofacial birth defect in humans and is notable for its apparent sexual dimorphism where approximately twice as many males are affected as females. The sources of this disparity are largely unknown, but interactions between genetic and sex effects are likely contributors. We examined gene‐by‐sex (G × S) interactions in a...

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