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Cancer Risk and Genetic Associations in Individuals With Cleft Lip and Palate and Their Families: A Narrative Review.

Birth defects research - 1 Sept 2025

Ghadbane Cesar, Maalouf Elisia, Boutros Tigresse, Ghadban Elie

Abstract excerpt

BACKGROUND: Orofacial clefts (OFCs) are among the most common craniofacial birth defects and have been investigated for possible associations with increased cancer risk in affected individuals and their families. METHOD: This narrative review synthesizes current evidence from epidemiological, familial, and genetic studies. RESULTS: Population-based and registry analyses have reported elevated risks of breast,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40937561
DOI: 10.1002/bdr2.2528

Genes

AXIN2
CDH1
BRCA1
BRIP1
E2F1
FOXE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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