Article
The Impact of ZIP8 Disease-Associated Variants G38R, C113S, G204C, and S335T on Selenium and Cadmium Accumulations: The First Characterization.
International journal of molecular sciences - 22 Oct 2021
Liang Zhan-Ling, Tan Heng Wee, Wu Jia-Yi, Chen Xu-Li, Wang Xiu-Yun, Xu Yan-Ming, Lau Andy T Y
Abstract excerpt
The metal cation symporter ZIP8 (SLC39A8) is a transmembrane protein that imports the essential micronutrients iron, manganese, and zinc, as well as heavy toxic metal cadmium (Cd). It has been recently suggested that selenium (Se), another essential micronutrient that has long been known for its role in human health and cancer risk, may also be transported by the ZIP8 protein. Several mutations in the ZIP8 gene...
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