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Emerging Roles of the Copper–CTR1 Axis in Tumorigenesis

23 May 2022

Abstract excerpt

Physiologic roles of copper in metabolic homeostasis have been well established; however, whether and how copper is dysregulated in tumors and contributes to tumorigenesis is not recapitulated. Here, we comprehensively summarize the potential origins of copper accumulation in diseases, especially in cancers, by dysregulating copper transporter 1 (CTR1) or ATPase copper transporting alpha/beta (ATP7A/B) and...

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PMID: 35604085
DOI: 10.1158/1541-7786.mcr-22-0056

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