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Article

Immunoglobulin γ allotypes influence the level of autoantibody responses to amyloid-β in patients with Alzheimer's disease.

Human immunology - 1 Jan 2026

Pandey Janardan P, Kimball Christine, Nietert Paul J, Lah James J, Levey Allan I

Abstract excerpt

Immunoglobulin GM (γ marker) allotypes, highly polymorphic hereditary antigenic determinants of IgG, have been shown to be a risk factor for the development of Alzheimer's disease (AD). The mechanisms underlying the GM-AD association are not understood. The aim of the present investigation was to determine whether GM genotypes influenced the level of naturally occurring antibodies to amyloid-β (Aβ), a hallmark of...

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Identifiers

PMID: 41371042
DOI: 10.1016/j.humimm.2025.111632
PMCID: PMC13006853

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