Article
Genome-wide association scan in HIV-1-infected individuals identifying variants influencing disease course.
PloS one - 1 Jan 2011
van Manen Daniëlle, Delaneau Olivier, Kootstra Neeltje A, Boeser-Nunnink Brigitte D, Limou Sophie, Bol Sebastiaan M, Burger Judith A, Zwinderman Aeilko H, Moerland Perry D, van 't Slot Ruben, Zagury Jean-François, van 't Wout Angélique B, Schuitemaker Hanneke
Abstract excerpt
BACKGROUND: AIDS develops typically after 7-11 years of untreated HIV-1 infection, with extremes of very rapid disease progression (<2 years) and long-term non-progression (>15 years). To reveal additional host genetic factors that may impact on the clinical course of HIV-1 infection, we designed a genome-wide association study (GWAS) in 404 participants of the Amsterdam Cohort Studies on HIV-1 infection and...
Topics
- Adult
- Cohort Studies
- Disease Progression
- Female
- Genome, Human
- Genome-Wide Association Study
- HIV Infections
- HIV-1
- Humans
- Male
- Middle Aged
- Netherlands
- Polymorphism, Single Nucleotide