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Article

A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients.

EMBO molecular medicine - 1 Mar 2011

Pothlichet Julien, Niewold Timothy B, Vitour Damien, Solhonne Brigitte, Crow Mary K, Si-Tahar Mustapha

Abstract excerpt

Dysregulation of the antiviral immune response may contribute to autoimmune diseases. Here, we hypothesized that altered expression or function of MAVS, a key molecule downstream of the viral sensors RIG-I and MDA-5, may impair antiviral cell signalling and thereby influence the risk for systemic lupus erythematosus (SLE), the prototype autoimmune disease. We used molecular techniques to screen non-synonymous...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to interferon and immune responses

Share to Interferon Type I

Share to Lupus Erythematosus, Systemic

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Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 21268286
DOI: 10.1002/emmm.201000120
PMCID: PMC3395111

Genes

MAVS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients.PMID 21268286Read ↗

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