Article
A Neanderthal Sodium Channel Increases Pain Sensitivity in Present-Day Humans.
Current biology : CB - 7 Sept 2020
Zeberg Hugo, Dannemann Michael, Sahlholm Kristoffer, Tsuo Kristin, Maricic Tomislav, Wiebe Victor, Hevers Wulf, Robinson Hugh P C, Kelso Janet, Pääbo Svante
Abstract excerpt
The sodium channel Nav1.7 is crucial for impulse generation and conduction in peripheral pain pathways [1]. In Neanderthals, the Nav1.7 protein carried three amino acid substitutions (M932L, V991L, and D1908G) relative to modern humans. We expressed Nav1.7 proteins carrying all combinations of these substitutions and studied their electrophysiological effects. Whereas the single amino acid substitutions do not...
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